Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

The review summarises the data of the last 50 years on the effectiveness of the amino acid L-
arginine in therapeutic practice in conditions accompanied by different-origin hypoxia. The …

Hypoxia is increasingly recognized as an important physiological driving force. A specific
transcriptional program, induced by a decrease in oxygen (O2) availability, for example …

Introduction: Worldwide, more than 5.7% of the population reside above 1,500 m of
elevation. It has been hypothesized that acute short-term hypoxia exposure could increase …

Hypoxia is caused by insufficient oxygen availability for the organism leading to reduced
oxygen delivery to tissues and cells. It has been regarded as a severe threat to human …

Background: There is limited information regarding the variation of the cardiovascular (CV)
risk, that combines multiple risk factors in one metric, according to urbanization and altitude …

To determine the association between altitude and the Framingham risk score in the
Peruvian population, we performed a cross-sectional analytical study of data collected by …

Healthy lifestyles, such as those that include regular physical activity and a balanced diet,
are a powerful means to prevent chronic disease and age-related functional decline. A …

Introduction About 5.7% of the world population resides above 1500 m. It has been
hypothesised that acute exposure to high-altitude locations can increase stroke risk, while …