Prior to 1981, treatment options for invasive fungal infections were limited and associated
with significant toxicities. The introduction of ketoconazole marked the beginning of an era of …

To evaluate the tolerability and liver safety profiles of the systemic antifungal agents
commonly used for the treatment of invasive fungal infection, we conducted a systematic …

Fungal species are a very important source of many different enzymes, and the ability of
fungi to transform steroids has been used for several decades in the production of …

Covering: 1955 to 2009 The preparation and biological properties of various AmB analogs
and conjugates that have been studied since the introduction of AmB into the clinic over 50 …

Background: During the last three decades systemic fungal infections associated to
immunosuppressive therapies have become a serious healthcare problem. Clinical …

This study aims to develop chitosan-based voriconazole nanoparticles (NPs) using spray-
drying technique. The effect of surfactants and polymers on the physicochemical properties …

Candida albicans has remained the main etiological agent of candidiasis, challenges
clinicians with high mortality and morbidity. The emergence of resistance to antifungal drugs …

Invasive aspergillosis has been studied in laboratory by the means of plethora of distinct
animal models. They were developed to address pathophysiology, therapy, diagnosis, or …

Background The prevalence of invasive fungal infections (IFIs) has increased steadily
worldwide in the last few decades. Particularly, there has been a global rise in the number of …

Glycosyltransferases (GTs) are a large family of enzymes that are essential in all domains of
life for the biosynthesis of complex carbohydrates and glycoconjugates. GTs catalyse the …