Antiphospholipid syndrome (APS) is an autoimmune thrombophilia propelled by circulating
antiphospholipid antibodies that herald vascular thrombosis and obstetrical complications …

Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

Antiphospholipid syndrome (APS) is a thrombo-inflammatory disease propelled by
circulating autoantibodies that recognize cell surface phospholipids and phospholipid …

Background The mechanisms of vascular thrombosis and pregnancy loss in the
antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid …

Abstract Annexin A5 (AnxA5) is a potent anticoagulant protein that crystallizes over
phospholipid bilayers (PLBs), blocking their availability for coagulation reactions …

Background Antiphospholipid antibodies (aPLs) are a heterogenous group of
autoantibodies associated with recurrent miscarriage, stillbirth, foetal growth restriction and …

In normal healthy cells phosphatidylserine is located in the inner leaflet of the plasma
membrane. However, on activated platelets, dying cells and under specific circumstances …

Abstract Treatment with the antimalarial drug hydroxychloroquine (HCQ) has been
associated with reduced risk of thrombosis in the antiphospholipid (aPL) syndrome (APS) …

Several modes of cell death are now recognized, including necrosis, apoptosis, and
autophagy. Oftentimes the distinctions between these various modes may not be apparent …

Acquired abnormalities in platelets, endothelium, and their interaction occur in sepsis,
immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome …