Integrins as biomechanical sensors of the microenvironment
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
[HTML][HTML] Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming
Z Li, C Sun, Z Qin - Theranostics, 2021 - ncbi.nlm.nih.gov
Cancer cells are well-known for adapting their metabolism to maintain high proliferation
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
The extracellular matrix modulates the metastatic journey
The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …
The spatial landscape of progression and immunoediting in primary melanoma at single-cell resolution
Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
Cell adhesion and matrix stiffness: coordinating cancer cell invasion and metastasis
V Gkretsi, T Stylianopoulos - Frontiers in oncology, 2018 - frontiersin.org
Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell
cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's …
cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's …
A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression
Alteration of tissue mechanical properties is a physical hallmark of solid tumors including
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Advanced solid cancers are complex assemblies of tumor, immune, and stromal cells
characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D …
characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D …
[HTML][HTML] Microenvironmental determinants of pancreatic cancer
E Hessmann, SM Buchholz, IE Demir… - Physiological …, 2020 - journals.physiology.org
Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems
The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …