[HTML][HTML] Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
[HTML][HTML] Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
[HTML][HTML] A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
Neuropathic pain: central vs. peripheral mechanisms
Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …
TNF-α differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury
Clinical studies show that chronic pain is accompanied by memory deficits and reduction in
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …
[HTML][HTML] Role of the immune system in neuropathic pain
M Malcangio - Scandinavian journal of pain, 2020 - degruyter.com
Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …
however pain can outlast its protective purpose and persist beyond injury, becoming …
Chronic pain and neuroinflammation
P Vergne-Salle, P Bertin - Joint Bone Spine, 2021 - Elsevier
In rheumatology, chronic pain most often sets in after a musculoskeletal injury. Its
persistence is not always due to the progression of the initial injury, but in some cases to the …
persistence is not always due to the progression of the initial injury, but in some cases to the …
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
Triggering receptor expressed on myeloid cell 2 (TREM2) is linked to risk of
neurodegenerative disease. However, the function of TREM2 in neurodegeneration is still …
neurodegenerative disease. However, the function of TREM2 in neurodegeneration is still …
Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration
R Feng, V Muraleedharan Saraswathy… - Proceedings of the …, 2023 - National Acad Sciences
Sensory neurons located in dorsal root ganglia (DRG) convey sensory information from
peripheral tissue to the brain. After peripheral nerve injury, sensory neurons switch to a …
peripheral tissue to the brain. After peripheral nerve injury, sensory neurons switch to a …