Regular endurance exercise induces skeletal muscle contractile and metabolic adaptations,
conferring salutary health benefits, such as protection against the metabolic syndrome. The …

Histone deacetylases (HDACs) regulate gene transcription by catalyzing the removal of
acetyl groups from key lysine residues in nucleosomal histones and via the recruitment of …

Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at
an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone …

Context: Exercise benefits most, but not all, individuals with type 2 diabetes (T2D). The
beneficial effects are well studied, but why some individuals do not respond favorably to …

Sprint interval training has been reported to induce similar or greater mitochondrial
adaptations to continuous training. However, there is limited knowledge about the effects of …

The mRNA of the nuclear coactivator peroxisome proliferator-activated receptor-γ
coactivator-1α (PGC-1α) increases during prolonged exercise and is influenced by …

We investigated the role of AMPKα2in basal, exercise training-, and AICAR-induced protein
expression of GLUT4, hexokinase II (HKII), mitochondrial markers, and AMPK subunits. This …

Data derived from several recent studies implicate peroxisome proliferator-activated
receptor-γ coactivator-1α (PGC-1α) in the pathogenesis of type 2 diabetes. Lacking DNA …

Highlights•Exercise alters the gene expression pattern in multiple tissues.•Regular exercise
can modify the genome-wide DNA methylation pattern in humans.•Regular exercise could …

The remodeling of the mitochondrial network is a critical process in maintaining cellular
homeostasis and is intimately related to mitochondrial function. The interplay between the …