In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …

Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …

Although the pre‐clinical study of chimeric antigen receptor (CAR)‐natural killer (NK) cell
was effective against various tumours, immunosuppression mediated by tumour …

Introduction Cell-based immunotherapy is categorized as a regenerative therapy under the
Regenerative Medicine Safety Act in Japan. Natural killer (NK) cell-based immunotherapy is …

Typical physiological characteristics of tumors, such as weak acidity, low oxygen content,
and upregulation of certain enzymes in the tumor microenvironment (TME), provide survival …

Extracellular vesicles (EVs) are increasingly recognized as important intermediaries of
intercellular communication. They have significant roles in many physiological and …

The evaluation of chronic pain is challenging because of the lack of specific biomarkers. We
identified the Mu opioid receptor-positive (Mu+) B cell percentage of expression, named Mu …

In recent years, great strides have been made toward the development of immune cell‐
based therapies in the treatment of refractory malignancies. Primary T cells and NK cells …

Owing to non-responsiveness of a high number of patients to the common melanoma
therapies, seeking novel approaches seem as an unmet requirement. Chimeric antigen …