Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in cannabis

AM Tomko, EG Whynot, LD Ellis, DJ Dupré - Cancers, 2020 - mdpi.com
In recent years, and even more since its legalization in several jurisdictions, cannabis and
the endocannabinoid system have received an increasing amount of interest related to their …

Mechanisms of cannabidiol (CBD) in cancer treatment: A review

CG Heider, SA Itenberg, J Rao, H Ma, X Wu - Biology, 2022 - mdpi.com
Simple Summary Emerging evidence suggests positive outcomes from the use of CBD as a
cancer treatment. CBD can relieve cancer pain and ease the side effects of chemotherapy; …

The effects of cannabidiol, a non-intoxicating compound of cannabis, on the cardiovascular system in health and disease

A Kicman, M Toczek - International journal of molecular sciences, 2020 - mdpi.com
Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis
which exhibits potential beneficial properties in a wide range of diseases, including …

Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?

V Martínez, A Iriondo De-Hond, F Borrelli… - International Journal of …, 2020 - mdpi.com
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …

Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination, and related clinical implications

E Perucca, M Bialer - CNS drugs, 2020 - Springer
This article provides a critical appraisal of the available evidence concerning clinical
exposure to orally administered cannabidiol (CBD), with special reference to factors …

Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol

P Alves, C Amaral, N Teixeira… - Pharmacological …, 2020 - Elsevier
Cannabis is the most used illicit drug worldwide and its medicinal use is under discussion,
being regulated in several countries. However, the psychotropic effects of Δ 9 …

Inclusion complexes of cannabidiol with β-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity

H Li, SL Chang, TR Chang, Y You, XD Wang… - Journal of Molecular …, 2021 - Elsevier
Cannabidiol (CBD), which has a wide variety of biological activities, is one of the
phytocannabinoids from Cannabis sativa L. However, due to the poor aqueous solubility, its …

A novel mechanism of cannabidiol in suppressing hepatocellular carcinoma by inducing GSDME dependent pyroptosis

F Shangguan, H Zhou, N Ma, S Wu… - Frontiers in cell and …, 2021 - frontiersin.org
Cannabidiol (CBD), a phytochemical derived from Cannabis sativa L., has been
demonstrated to exhibit promising anti-tumor properties in multiple cancer types. However …

Cannabinoids in the pathophysiology of skin inflammation

C Scheau, IA Badarau, LG Mihai, AE Scheau… - Molecules, 2020 - mdpi.com
Cannabinoids are increasingly-used substances in the treatment of chronic pain, some
neuropsychiatric disorders and more recently, skin disorders with an inflammatory …

Modulatory effect of gut microbiota on the gut-brain, gut-bone axes, and the impact of cannabinoids

I Ibrahim, S Syamala, JA Ayariga, J Xu, BK Robertson… - Metabolites, 2022 - mdpi.com
The gut microbiome is a collection of microorganisms and parasites in the gastrointestinal
tract. Many factors can affect this community's composition, such as age, sex, diet …