[HTML][HTML] RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives

Y Chen, Z Jiang, Y Yang, C Zhang, H Liu… - International Journal of …, 2023 - Elsevier
RNA methylation, an epigenetic modification that does not alter gene sequence, may be
important to diverse biological processes. Protein regulators of RNA methylation include …

[HTML][HTML] RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

WW Liu, SQ Zheng, T Li, YF Fei, C Wang… - … and Targeted Therapy, 2024 - nature.com
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis
requirements of cells. Relevant studies have been constantly making inroads in our …

[HTML][HTML] Blocking tri-methylguanosine synthase 1 (TGS1) stops anchorage-independent growth of canine sarcomas

D Zucko, K Boris-Lawrie - Cancer gene therapy, 2023 - nature.com
Abstract Tri methylguanosine synthase 1 (TGS1) is the enzyme that hyper methylates the
hallmark 7-methyl-guanosine cap (m7G-cap) appended to the transcription start site of …

The eukaryotic translation initiation factor eIF4E reprograms alternative splicing

M Ghram, G Morris, B Culjkovic‐Kraljacic… - The EMBO …, 2023 - embopress.org
Aberrant splicing is typically attributed to splice‐factor (SF) mutation and contributes to
malignancies including acute myeloid leukemia (AML). Here, we discovered a mutation …

Game of Omes: ribosome profiling expands the MHC-I immunopeptidome

J Holly, JW Yewdell - Current Opinion in Immunology, 2023 - Elsevier
Peptide ligands presented by cell-surface MHC class-I molecules enable T cells to eradicate
intracellular pathogens and cancers. The presented peptide repertoire, the class-I …

[HTML][HTML] The role of RNA methylation in tumor immunity and its potential in immunotherapy

Y Li, H Jin, Q Li, L Shi, Y Mao, L Zhao - Molecular Cancer, 2024 - Springer
RNA methylation, a prevalent post-transcriptional modification, has garnered considerable
attention in research circles. It exerts regulatory control over diverse biological functions by …

The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation: eIF4E induces widescale splicing …

KLB Borden - BioEssays, 2024 - Wiley Online Library
Recent findings position the eukaryotic translation initiation factor eIF4E as a novel
modulator of mRNA splicing, a process that impacts the form and function of resultant …

[HTML][HTML] M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

M Han, Q Huang, X Li, X Chen, H Zhu… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
RNA modifications play a pivotal role in regulating cellular biology by exerting influence over
distribution features and molecular functions at the post-transcriptional level. Among these …

Critical roles and clinical perspectives of RNA methylation in cancer

G Li, Q Yao, P Liu, H Zhang, Y Liu, S Li, Y Shi, Z Li… - MedComm, 2024 - Wiley Online Library
RNA modification, especially RNA methylation, is a critical posttranscriptional process
influencing cellular functions and disease progression, accounting for over 60% of all RNA …