Abstract Background Cancer-induced Bone Pain (CIBP) is an important factor affecting their
quality of life of cancer survivors. In addition, current clinical practice and scientific research …

Chemotherapy-induced neuropathic pain (CINP) is one of the most severe side effects of
anticancer agents, such as platinum-and taxanes-derived drugs (oxaliplatin, cisplatin …

The side-effects and long-term sequelae of anti-cancer chemotherapy remain a major
source of concern for both patients and clinicians despite the improved efficacy and …

Background and Purpose Gout arthritis, which is provoked by monosodium urate (MSU)
crystal accumulation in the joint and periarticular tissues, induces severe pain and affects …

Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Innate immune response acts as the first line of host defense against damage and is initiated
following the recognition of pathogen-associated molecular patterns (PAMPs). For double …

Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death.
Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain …

Paclitaxel-induced neuropathic pain (PINP) is refractory to currently used analgesics.
Previous studies show a pivotal role of oxidative stress in PINP. Because the nuclear factor …

Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDS) produce deleterious side
effects and fail to provide sustained relief in patients with chronic inflammatory pain …

Chronic pain remains an enormous health problem affecting approximatively 30% of the
world's population. Opioids as the first line analgesics often leads to undesirable side effects …