Pathophysiology and pharmacological treatment of insulin resistance

S Matthaei, M Stumvoll, M Kellerer… - Endocrine …, 2000 - academic.oup.com
Diabetes mellitus type 2 is a world-wide growing health problem affecting more than 150
million people at the beginning of the new millennium. It is believed that this number will …

Type 2 diabetes mellitus in Canada ‚s First Nations: status of an epidemic in progress

TK Young, J Reading, B Elias - Cmaj, 2000 - Can Med Assoc
THIS REVIEW PROVIDES A STATUS REPORT ON THE EPIDEMIC of type 2 diabetes
mellitus that is affecting many of Canada ‚s First Nations. We focus on the published …

[图书][B] Aboriginal health in Canada: Historical, cultural, and epidemiological perspectives

JB Waldram, A Herring, TK Young - 2006 - books.google.com
Numerous studies, inquiries, and statistics accumulated over the years have demonstrated
the poor health status of Aboriginal peoples relative to the Canadian population in general …

[PDF][PDF] Genomewide search for type 2 diabetes–susceptibility genes in French Whites: evidence for a novel susceptibility locus for early-onset diabetes on …

N Vionnet, S Dupont, S Gallina, S Francke… - The American Journal of …, 2000 - cell.com
Despite recent advances in the molecular genetics of type 2 diabetes, the majority of
susceptibility genes in humans remain to be identified. We therefore conducted a 10-cM …

[PDF][PDF] Genomewide scans of complex human diseases: true linkage is hard to find

J Altmüller, LJ Palmer, G Fischer, H Scherb… - The American Journal of …, 2001 - cell.com
Many" complex" human diseases, which involve multiple genetic and environmental
determinants, have increased in incidence during the past 2 decades. During the same time …

The genetic landscape of type 2 diabetes in mice

SM Clee, AD Attie - Endocrine reviews, 2007 - academic.oup.com
Inbred mouse strains provide genetic diversity comparable to that of the human population.
Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse …

A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic …

S Francke, M Manraj, C Lacquemant… - Human Molecular …, 2001 - academic.oup.com
Prevalence of coronary heart disease (CHD), of type 2 diabetes (T2DM) and of the metabolic
syndrome are in Mauritius amongst the highest in the world. As T2DM and CHD are closely …

Defining the genetic contribution of type 2 diabetes mellitus

J van Tilburg, TW Van Haeften, P Pearson… - Journal of medical …, 2001 - jmg.bmj.com
Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined
by several different genes and environmental factors. It now affects 150 million people world …

Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome …

WC Hsueh, PL St. Jean, BD Mitchell, TI Pollin… - Diabetes, 2003 - Am Diabetes Assoc
We conducted a genome scan using a 10-cM map to search for genes linked to type 2
diabetes in 691 individuals from a founder population, the Old Order Amish. We then …

Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies

CF Weijnen, SS Rich, JB Meigs, AS Krolewski… - Diabetic …, 2002 - Wiley Online Library
Aims The goal was to estimate the sibling recurrence‐risk ratio for Type 2 diabetes in
families with diabetes occurring in middle age. Because diabetes aetiology involves …