Repurposing FDA-approved anti-diabetic drug to target H. pylori peptidyl deformylase using computer-based drug discovery approach
Peptide deformylase (PDF), a metalloenzyme is an important and attractive target in
antibacterial drug discovery. It removes the N-formyl group from the nascent peptide and …
antibacterial drug discovery. It removes the N-formyl group from the nascent peptide and …
In silico identification of potential γ-secretase inhibitor of marine-algal origin: an anticancer intervention
Gamma secretase (GS) activates notch signalling pathway (NSP) by liberating the truncated
notch intracellular domain (NICD). The NSP is associated with the cancer development and …
notch intracellular domain (NICD). The NSP is associated with the cancer development and …
[PDF][PDF] Identification of novel indole derivatives as potent α-amylase inhibitors for the treatment of type-II diabetes using in-silico approaches
The α-amylase is regarded as a promising drug target for diabetes mellitus-type II. Hence,
inhibiting α-amylase activity is a potential drug discovery approach for treating this chronic …
inhibiting α-amylase activity is a potential drug discovery approach for treating this chronic …
Targeting the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) with synthetic/designer unnatural nucleoside analogs: an in silico study
Context Since the outbreak of COVID-19 in December 2019, it developed into a pandemic
affecting all the countries and millions of people around the globe. Until now, there is no …
affecting all the countries and millions of people around the globe. Until now, there is no …
Exploring the mangrove based phytochemicals as potential viral RNA helicase inhibitors by in silico docking and molecular dynamics simulation method
R Satpathy, S Acharya - Математическая биология и …, 2023 - mathnet.ru
The high molecular diversity of plant-derived compounds in mangroves has drawn attention
to the discovery of their antiviral capacity against several pathogenic viruses. Therefore …
to the discovery of their antiviral capacity against several pathogenic viruses. Therefore …
Two-component EvgS protein subdues both antimicrobial resistance and virulence in Shigella flexneri 2a str. 301
Shigella flexneri 2a is one of the leading bacterial agents of diarrhoeal mortality in humans.
Recently, multi-drug resistance strains have posed severe challenges. The present study …
Recently, multi-drug resistance strains have posed severe challenges. The present study …
[HTML][HTML] A hypothesis on designing strategy of effective RdRp inhibitors for the treatment of SARS-CoV-2
Vaccines are used as one of the major weapons for the eradication of pandemic. However,
the rise of different variants of the SARS-CoV-2 virus is creating doubts regarding the end of …
the rise of different variants of the SARS-CoV-2 virus is creating doubts regarding the end of …
Clinical and molecular analysis of a novel variant responsive to salbutamol monotherapy during COVID-19 outbreak related to congenital and late-onset of …
Background: Congenital myasthenic syndromes (CMSs) are a group of clinically and
genetically heterogeneous disorders. Mutations in the DOK7 gene underlie CMS with …
genetically heterogeneous disorders. Mutations in the DOK7 gene underlie CMS with …
Designing of neoepitopes based vaccine against breast cancer using integrated immuno and bioinformatics approach
Cancer is characterized by genetic instability due to accumulation of somatic mutations in
the genes which generate neoepitopes (mutated epitopes) for targeting by Cytotoxic T …
the genes which generate neoepitopes (mutated epitopes) for targeting by Cytotoxic T …
[PDF][PDF] Discovery of natural anti-apoptotic protein inhibitor using molecular docking and MM-GBSA Approach: An anticancer intervention
Apoptosis is a programmed molecular phenomenon in normal cells, and" evading
apoptosis" is a hallmark of cancer. Overexpression of anti-apoptotic BCL-2 promotes cancer …
apoptosis" is a hallmark of cancer. Overexpression of anti-apoptotic BCL-2 promotes cancer …