Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

Mitochondrial fission is a highly regulated process that, when disrupted, can alter
metabolism, proliferation and apoptosis,–. Dysregulation has been linked to …

Cellular models are needed to study human development and disease in vitro, and to
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …

Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …

Prompt coronary catheterization and revascularization have markedly improved the
outcomes of myocardial infarction, but have also resulted in a growing number of surviving …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

Human diseases are often caused by loss of somatic cells that are incapable of re-entering
the cell cycle for regenerative repair. Here, we report a combination of cell-cycle regulators …

Background: circRNAs (circular RNAs) are emerging as powerful regulators of cardiac
development and disease, but their roles in cardiac regeneration are still unknown. This …