Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

It has been established that 4.4 to 20% of the general population suffers from a major
depressive disorder (MDD), which is frequently associated with a dysregulation of normal …

Circadian rhythms are near 24-h patterns of physiology and behaviour that are present
independent of external cues including hormones, body temperature, mood, and sleep …

Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …

The circadian nature of mood and its dysfunction in affective disorders is well recognized,
but the underlying molecular mechanisms are still unclear. Here, we show that the circadian …

Mood disorders (depression, bipolar disorders) are prevalent and disabling. They are also
highly co-morbid with other psychiatric disorders. Currently there are no objective measures …

Daily rhythms in behavior and physiology are programmed by a hierarchical collection of
biological clocks located throughout the brain and body, known as the circadian system …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

Background Major depressive disorder is associated with disturbed circadian rhythms. To
investigate the causal relationship between mood disorders and circadian clock disruption …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …