Mouse models of sickle cell disease: imperfect and yet very informative
S Kamimura, M Smith, S Vogel, LEF Almeida… - Blood Cells, Molecules …, 2024 - Elsevier
The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …
few therapies to treat the disease are available. Over several decades of work, with …
Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory …
W Li, AQ Pucka, C Debats, BA Reyes, F Syed… - Frontiers in …, 2024 - frontiersin.org
This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …
Discovery of potent DNMT1 inhibitors against sickle cell disease using structural-based virtual screening, MM-GBSA and molecular dynamics simulation-based …
Sickle cell disease (SCD) is an autosomal recessive genetic disorder affecting millions of
people worldwide. A reversible and selective DNMT1 inhibitor, GSK3482364, has been …
people worldwide. A reversible and selective DNMT1 inhibitor, GSK3482364, has been …
Atrial Arrhythmia in Sickle Cell Anemia Adults: A missing link towards understanding and preventing strokes
T d'Humières, Z Sadraoui, L Savale, L Boyer, H Guillet… - Blood Advances, 2024 - Elsevier
Although sickle cell disease (SCD) patients carry both significant left atrial (LA) remodeling
and increased risk of stroke, the prevalence of atrial arrhythmia (AA) has never been …
and increased risk of stroke, the prevalence of atrial arrhythmia (AA) has never been …
[HTML][HTML] Ferroptosis as an emerging target in sickle cell disease
V Fortuna, J Lima, GF Oliveira, YS Oliveira… - Current Research in …, 2024 - Elsevier
Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell
sickling, resulting in severe anemia, painful episodes, extensive organ damage, and …
sickling, resulting in severe anemia, painful episodes, extensive organ damage, and …