Increasing evidence has challenged the traditional view about the immune privilege of the
brain, but the precise roles of immune cells in regulating brain physiology and function …

Eosinophils play a pivotal role in the inflammatory pathology of asthma and have been the
target of new biologic treatments for patients with eosinophilic asthma. Given the central role …

Airway eosinophils are increased in asthma and are especially abundant around airway
nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where …

The goal of this series is to offer a survey of the latest literature for clinicians and scientists
alike, providing a list of important recent advances relevant to the broad field of allergy and …

Since their discovery, innate lymphoid cells (ILCs) have been described as the innate
counterpart of the T cells. Indeed, ILCs and T cells share many features including their …

The initiation of type 2 immune responses at mucosal barriers is regulated by rapidly
secreted cytokines called alarmins. The alarmins IL-33, IL-25 and TSLP are mainly secreted …

Eosinophils play a key role in airway inflammation in many diseases, such as allergic and
non-allergic asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive …

Asthma is now recognized as a heterogeneous disease, encompassing different
phenotypes driven by distinct pathophysiological mechanisms called endotypes. Common …

Eosinophils are bone marrow-derived granulocytes that, under homeostatic conditions,
account for as much as 1-3% of peripheral blood leukocytes. During inflammation …

Airway inflammation in asthma involves complex, interactive, and redundant cascades
mediated by an array of proinflammatory cytokines, including a type 2 (T2) pattern of injury …