Eosinophils play a pivotal role in the inflammatory pathology of asthma and have been the
target of new biologic treatments for patients with eosinophilic asthma. Given the central role …

Asthma is now recognized as a heterogeneous disease, encompassing different
phenotypes driven by distinct pathophysiological mechanisms called endotypes. Common …

Eosinophils are circulating granulocytes that have pleiotropic effects in response to
inflammatory signals in the body. In response to allergens or pathogens, exposure …

Eosinophils are typically considered tissue-damaging effector cells in type 2 immune-related
diseases. However, they are also increasingly recognized as important modulators of …

We sought to examine the regulatory effect of Meteorin-β (Metrnβ)/Meteorin like (Metrnl)/IL-
41 on lung inflammation in allergic asthma. We found that Metrnβ was elevated significantly …

Background In mice models, eosinophils have been divided into different subpopulations
with distinct phenotypes and functions, based on CD62L and CD101 patterns of membrane …

Eosinophils are innate immune cells typically associated with allergic and parasitic
diseases. However, in recent years, eosinophils have also been ascribed a role in keeping …

Eosinophils are rare, multifunctional granulocytes. Their growth, survival, and tissue
migration mainly depend on interleukin (IL)-5 in physiological conditions and on IL-5 and IL …

Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a
plethora of responses ranging from regulation of tissue homeostasis to host defense and …

Accumulating data have indicated a fundamental role of eosinophils in regulating adipose
tissue homeostasis. Here, we performed whole-genome RNA sequencing of the small …