Available information indicates that about 78 new molecules belonging to the class of
angiotensin converting enzyme (ACE) inhibitors are under investigation, and that at least 11 …

Analogues of captopril, enalaprilat, and the phosphinic acid [[hydroxy (4-phenylbutyl)
phosphinyl] acetyl]-L-proline incorporating 4-substituted proline derivatives have been …

1. Cilazapril is the monoethyl ester prodrug form of the di‐acid cilazaprilat, a new
angiotensin converting enzyme (ACE) inhibitor. Cilazaprilat has an IC50 of 1.9 nM as an …

Peptides and proteins are involved in controlling a large number of biological functions in
various life forms. In man, some of the peptides are released from endocrine glands into …

Synopsis Spirapril is a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor pro-
drug which is converted to the active metabolite spiraprilat following oral administration, and …

The pharmacokinetics and haemodynamic effects of orally administered spirapril, a novel
angiotensinconverting enzyme (ACE) inhibitor, have been investigated in patients with liver …

Sixteen essential hypertensive patients were entered into a protocol assessing the effect of
Spirapril, an angiotensin‐converting enzyme (ACE) inhibitor, on blood pressure, the renin …

Neutral endopeptidase (NEP) is an abundant, zinc-containing metalloendopeptidase which
was discovered in three converging lines of investigation during the past two decades. It was …

Ангаотензин-превращающий фермент (АПФ)-это Zn-зависимая протеиназа,
участвующая в метаболизме важнейших вазоактивных пептидов ренин …

The antihypertensive activity of spirapril given alone or in combination with felodipine was
investigated in spontaneously hypertensive rats (SHR) during a 3-week treatment regimen …