Genetic architecture of schizophrenia: a review of major advancements
SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …
technological advancements have led to a substantial increase in knowledge of the genetic …
Cognitive impairment associated with schizophrenia: from pathophysiology to treatment
DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry
and lack diversity. To overcome this limitation, we aggregated genome-wide association …
and lack diversity. To overcome this limitation, we aggregated genome-wide association …
Synergistic effects of common schizophrenia risk variants
The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …
Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders
Psychiatric disorders impose tremendous economic burden on society and are leading
causes of disability worldwide. However, only limited drugs are available for psychiatric …
causes of disability worldwide. However, only limited drugs are available for psychiatric …
Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons
Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene
mutation associated with schizophrenia, and additionally predispose to multiple other …
mutation associated with schizophrenia, and additionally predispose to multiple other …
[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?
J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …
conferring risk to the disorder. This progress offers an important route toward defining the …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …
Genome-wide association studies of schizophrenia and bipolar disorder in a diverse cohort of US veterans
Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating
neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing …
neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing …
Investigating the shared genetic architecture between schizophrenia and body mass index
Y Yu, Y Fu, Y Yu, M Tang, Y Sun, Y Wang… - Molecular …, 2023 - nature.com
Evidence for reciprocal comorbidity of schizophrenia (SCZ) and body mass index (BMI) has
grown in recent years. However, little is known regarding the shared genetic architecture or …
grown in recent years. However, little is known regarding the shared genetic architecture or …