Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

Osteosarcoma Osteosarcoma, which is most common in people 10 to 30 years of age, is
generally treated with resection and adjuvant chemotherapy. Detection of gene …

Background Osteosarcoma is the most common primary bone malignancy. As a rare cancer,
population‐based studies remain small with limited information on finer demographic …

We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …

Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome that is inherited in an
autosomal dominant pattern, is continuing to raise great interest for endocrinology …

Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent
patients characterized by high risk of metastatic progression and recurrence after therapy …

Osteosarcoma is the most common primary bone sarcoma and is often diagnosed in the 2nd–
3rd decades of life. Response to the aggressive and highly toxic neoadjuvant methotrexate …

The spectrum of germline predisposition in pediatric cancer continues to be realized. Here
we report 751 patients with solid tumors who underwent prospective matched tumor–normal …

Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high
propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS …

PURPOSE: Historically, cancer predisposition syndromes (CPSs) were rarely established for
children with cancer. This nationwide, population-based study investigated how frequently …