Enterovirus-induced infection of the central nervous system (CNS) results in acute
inflammation of the brain (encephalitis) and constitutes a significant global burden to human …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

The early stages of type 1 diabetes (T1D) are characterized by local autoimmune
inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show …

Background DNA methylation is influenced by both environmental and genetic factors and is
increasingly thought to affect variation in complex traits and diseases. Yet, the extent of …

Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular
disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare …

Recent advancements in single-cell technologies have enabled expression quantitative trait
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …

Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for
interpreting disease-associated variants, and context-specific QTLs show particular …

Genetic effects on gene expression and splicing can be modulated by cellular and
environmental factors; yet interactions between genotypes, cell type, and treatment have not …

The eQTL Catalogue is an open database of uniformly processed human molecular
quantitative trait loci (QTLs). We are continuously updating the resource to further increase …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …