Thousands of common genetic variants in the human population have been associated with
disease risk and phenotypic variation by genome-wide association studies (GWAS) …

Understanding the causal processes that contribute to disease onset and progression is
essential for developing novel therapies. Although trans-acting expression quantitative trait …

Genetic regulation of gene expression underlies variation in disease risk and other complex
traits. The effect of expression quantitative trait loci (eQTLs) varies across cell types; …

Chronic immune-mediated diseases of adulthood often originate in early childhood. To
investigate genetic associations between neonatal immunity and disease, we map …

Synthetic glucocorticoids, such as dexamethasone, have been used as a treatment for many
immune conditions, such as asthma and, more recently, severe COVID-19. Single-cell data …

Background Chromatin states and enhancers associate gene expression, cell identity and
disease. Here, we systematically delineate the acute innate immune response to endotoxin …

Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …

In the past 15 years, major progresses have been made in the understanding of the genetic
basis of regulation of gene expression. These new insights have revolutionized our …

Background Genome-wide association studies have identified dozens of genetic risk loci for
Alzheimer's disease (AD), yet the underlying causal variants and biological mechanisms …

Quantitative trait loci (QTL) analysis is an important approach to investigate the effects of
genetic variants identified through an increasing number of large-scale, multidimensional …