Genome-wide association studies of primary sclerosing cholangitis have identified 23
susceptibility loci. The majority of these loci reside in non-coding regions of the genome and …

Background A detailed understanding of genetic variants that affect beef merit helps
maximize the efficiency of breeding for improved production merit in beef cattle. To prioritize …

There is increasing appreciation that, in addition to being shaped by an individual's
genotype and environment, most complex traits are also determined by poorly understood …

Human large-scale genetic association studies have identified sequence variations at
thousands of genetic risk loci that are more common in patients with diverse metabolic …

Genome-wide association studies reveal the complex polygenic architecture underlying
psychiatric disorder risk, but there is an unmet need to validate causal variants, resolve their …

Genome-wide association studies (GWASs) have identified thousands of non-coding
variants that are associated with human complex traits and diseases. The analysis of such …

Interferons (IFNs) are cytokines that are central to the host defence against viruses and other
microorganisms. If not properly regulated, IFNs may contribute to the pathogenesis of …

Coronary artery disease is a complex cardiovascular disease involving an interplay of
genetic and environmental influences over a lifetime. Although considerable progress has …

Background A major issue with the current management of psoriasis is our inability to predict
treatment response. Objective Our aim was to evaluate the ability to use baseline molecular …

Systemic lupus erythematosus (SLE or lupus)(OMIM: 152700) is a chronic autoimmune
disease with debilitating inflammation that affects multiple organ systems. The STAT1 …