Abstract Objective Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
are severe cutaneous adverse drug reactions. Antiseizure medications (ASMs) with aromatic …

Abstract Changes in gene regulation have long been thought to play an important role in
primate evolution. However, although a number of studies have compared genome-wide …

Splicing quantitative trait loci (QTLs) have been implicated as a common mechanism
underlying complex trait associations. However, utilising splicing QTLs in target discovery …

The differentiation of resident intestinal macrophages from blood monocytes depends upon
signals from the macrophage colony-stimulating factor receptor (CSF1R). Analysis of …

Circular RNAs (circRNAs) are a class of non-coding RNAs that have cell-type-specific
expression and are relevant in cardiovascular disease. Aortic smooth muscle cells (SMCs) …

The LabEx Milieu Interieur (MI) project is a clinical study centered on the detailed
characterization of the baseline and induced immune responses in blood samples from …

Background Resistance to enteric pathogens is a complex trait at the crossroads of multiple
biological processes. We have previously shown in the Drosophila Genetic Reference Panel …

Sand flies are hematophagous insects responsible for the transmission of vector-borne
diseases to humans. Prominent among these diseases is Leishmaniasis that affects the skin …

The nuclear genome drives differences in immune cell populations and differentiation
potentials, in part regulated by changes in metabolism. Despite this connection, the role of …

D'où venons-nous? Que sommes-nous? Où allons-nous? C'est à ces questions universelles
que répond ce livre. Lluís Quintana-Murci, biologiste franco-espagnol de renommée …