Impact of the Human Cell Atlas on medicine
JE Rood, A Maartens, A Hupalowska, SA Teichmann… - Nature medicine, 2022 - nature.com
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …
therapies. By identifying the specific cell types, states, programs and contexts where disease …
Applications of single-cell sequencing in cancer research: progress and perspectives
Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial
Abstract Neoadjuvant ipilimumab+ nivolumab (Ipi+ Nivo) and nivolumab+ chemotherapy
(Nivo+ CT) induce greater pathologic response rates than CT alone in patients with …
(Nivo+ CT) induce greater pathologic response rates than CT alone in patients with …
[HTML][HTML] Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and spatial transcriptomics
J Zhu, Y Fan, Y Xiong, W Wang, J Chen, Y Xia… - … & Molecular Medicine, 2022 - nature.com
The cell ecology and spatial niche implicated in the dynamic and sequential process of lung
adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive …
adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive …
Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression
Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma
(GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell …
(GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell …
[HTML][HTML] Radiomics and artificial intelligence for precision medicine in lung cancer treatment
Lung cancer is the leading cause of cancer-related deaths worldwide. It exhibits, at the
mesoscopic scale, phenotypic characteristics that are generally indiscernible to the human …
mesoscopic scale, phenotypic characteristics that are generally indiscernible to the human …
The single-cell immunogenomic landscape of B and plasma cells in early-stage lung adenocarcinoma
Tumor-infiltrating B and plasma cells (TIB) are prevalent in lung adenocarcinoma (LUAD);
however, they are poorly characterized. We performed paired single-cell RNA and B-cell …
however, they are poorly characterized. We performed paired single-cell RNA and B-cell …
B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity
CM Laumont, BH Nelson - Cancer Cell, 2023 - cell.com
Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …