Drug conjugates, including antibody-drug conjugates, are a step toward realizing Paul
Ehrlich's idea from over 100 years ago of a “magic bullet” for cancer treatment. Through …

Cytotoxic chemotherapy remains a key modality in cancer treatment. These therapies,
successfully used for decades, continue to transform the lives of cancer patients daily. With …

Exatecan and deruxtecan are antineoplastic camptothecin derivatives in development as
tumor-targeted-delivery warheads in various formulations including peptides, liposomes …

Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that
prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment …

Despite significant progress in the development of novel STING agonists (STINGa),
applications appear to be challenged by the low efficiency and poor selectivity of these …

Nitro fatty acids (NO 2-FAs) are endogenously generated lipid signaling mediators from
metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide …

Targeting enzymes involved in tumor metabolism is a promising way to tackle cancer
progression. The inhibition of carnitine palmitoyltransferase 1 (CPT1) by etomoxir (Eto) …

Doxorubicin (DOX) is widely used in the treatment of many tumors, but the dose-dependent
toxicity limits its further application. In this study, a unique strategy was developed to improve …

Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here
we report the targeted delivery of various epitopes, including a peptide, a small molecule …

To improve targeted cargo delivery to cancer cells, pH-Low Insertion Peptide (pHLIP)
variants were developed to interact with the membrane at pH values higher than those of the …