Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular
signals are transduced via dedicated signalling pathways and mostly converge to MITF, a …

Human skin, eye and hair color rely on the production of melanin, depending on its quantity,
quality, and distribution, Melanin plays a monumental role in protecting the skin against the …

Hyperpigmentation is a common and distressing dermatologic condition. Since tyrosinase
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …

Background Melanin plays an important role in protecting human skin, while excessive
synthesis of melanin can cause abnormal pigmentation and induce skin diseases. Long …

The history of cosmetics goes back to early Egyptian times for hygiene and health benefits
while the history of topical applications that provide a medicinal treatment to combat dermal …

Melasma is a common acquired disorder of pigmentation that negatively impacts quality of
life. Present treatments show poor therapeutic effect with frequent recurrence. This in large …

Withaferin A (WA) is a pivotal withanolide that has conquered a conspicuous place in
research, owning to its multidimensional biological properties. It is an abundant constituent …

The production of melanin pigments by melanocytes and their quantity, quality, and
distribution play a decisive role in determining human skin, eye, and hair color, and protect …

Pigmentation diseases can lead to significant color differences between the affected part
and the normal part, resulting in severe psychological and emotional distress among …