Osteoarthritis (OA) is one of the most common joint diseases, there are no effective disease-
modifying drugs, and the pathological mechanisms of OA need further investigation. Here …

Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of
cancer. Whether the biomechanical property of ECM impacts the functionality of tumor …

Transcriptional regulation is pivotal to the specification of distinct cell types during embryonic
development. However, it still lacks a systematic way to identify key transcription factors …

The evolution and development of vertebrate lungs have been widely studied due to their
significance in terrestrial adaptation. Amphibians possess the most primitive lungs among …

Background: Normal fusion of the upper lip and primary palate is a complex process
involving a series of characteristic and orderly regulated cellular events. Cleft lip with or …

For the digestion of food, it is important for the gut to be differentiated regionally and to have
proper motor control. However, the number of transcription factors that regulate its …

The fin-to-limb transition is an important evolutionary step in the colonization of land and
diversification of all terrestrial vertebrates. We previously identified a gene family in …

The proximal convoluted tubule (PCT) of the kidney is a crucial functional segment
responsible for reabsorption, secretion, and the maintenance of electrolyte and water …

The musculoskeletal system is composed of muscles, skeletal elements and connective
tissues such as tendon and muscle connective tissue. Muscle connective tissue contributes …

Skeletal muscle maintenance and repair is performed by resident stem cells, called satellite
cells. The muscular dystrophies are a group of disorders which are characterised by …