In spite of the continuous improvement in our knowledge of the nature of cancer, the causes
of its formation and the development of new treatment methods, our knowledge is still …

The area of marine hypoxia is gradually expanding. This phenomenon seriously affects the
normal life activities of a variety of marine organisms. Japanese flounder (Paralichthys …

The mammalian target of rapamycin (mTOR) pathway is an highly conserved signal
transduction axis involved in many cellular processes, such as cell growth, survival …

Fracture repair is a complex process involving timed cellular recruitment, gene expression,
and synthesis of compounds that regenerate native tissue to restore the mechanical …

Introduction As a common complication of spinal cord injury (SCI), most SCI patients suffer
from osteoporosis. In our previous study, chronic intermittent hypobaric hypoxia (CIHH) …

The increasing importance of hypoxia-inducible factor-1α (HIF-1α) in tumorigenesis raises
the possibility that agents which specifically inhibit this transcription factor, would provide …

Bone loss due to smoking represents a major risk factor for fractures and bone osteoporosis.
Signaling through the aryl hydrocarbon receptor (AhR) and its ligands contributes to both …

Axial micromotion of bone fragments promotes callus formation and bone healing during the
process of distraction osteogenesis (DO). This study investigated the effects of the combined …

The effect of chronic intermittent hypobaric hypoxia (CIHH) on bone fracture healing is not
elucidated. The present study aimed to investigate the role of CIHH on bone fracture healing …

Abstract Biodegradable PLA-PEG-PLA block copolymers were synthesized with desired
backbone structures and molecular weights using PEG20000. Rectangular scaffolds were …