Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …

Commonly consumed foods and beverages can contain chemicals with reported
carcinogenic activity in rodent models. Moreover, exposures to some of these substances …

Globally, industries and regulatory authorities are faced with an urgent need to assess the
potential adverse effects of chemicals more efficiently by embracing new approach …

Highlights•Pesticides•Toxicological data requirements and evaluation•Reference
values•NOAEL vs. Benchmark dose approach•New approach methodologies (NAMs)Due to …

The conventional battery for genotoxicity testing is not well suited to assessing the large
number of chemicals needing evaluation. Traditional in vitro tests lack throughput, provide …

Regulatory science, rooted in legal requirements, provides a mechanism for identifying,
assessing, and managing harm to humans and the environment from exposure to …

Although there are a number of guidance documents and frameworks for evaluation of
carcinogenicity, none of the current methods fully reflects the state of the science. Common …

Chemical grouping and read-across are frequently used non-animal alternatives for filling
toxicological data gaps. When grouping chemicals, it is critical to define the applicability …

Dioxane is an environmental contaminant that has been shown to cause cancer in rodents
after chronic high dose exposures. We reviewed and integrated information from recently …

The field of risk assessment, which was pioneered by Arnold Lehmann when at the FDA in
1954, was formally adopted by all agencies as an important way to assess chemical and …