The inflammatory response and the activation of coagulation are two important responses in
a host's defense against infection. These mechanisms do not work independently, but …

In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents
the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet …

In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

Acute respiratory distress syndrome (ARDS) is defined as a syndrome of acute onset, with
bilateral opacities on chest imaging and respiratory failure not caused by cardiac failure …

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous
thrombosis (DVT), is a common and severe complication of critical illness. Although well …

Platelets are small circulating anucleate cells that are of crucial importance in haemostasis.
Over the last decade, it has become increasingly clear that platelets play an important role in …

COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia,
exhausted lymphocytes and a cytokine storm. Several reports from around the world have …

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Platelets have received increasing attention for their role in the pathophysiology of infectious
disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known …

Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …