Introduction: Neuropathic pain affects up to 8% of the population with few therapeutic
options for its management. No specific drugs are approved for its treatment. Areas covered …

Abstract Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …

A series of benzene sulfonamide carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors which
incorporate lipophilic 4-alkoxy-and 4-aryloxy moieties, together with several derivatives of …

The wide biological actions of triazolotriazine hybrids, benzene‐sulfonamide derivatives,
exhibit a good chance of displaying in vitro anti‐inflammatory effects. An operationally …

Herein we report the design as well as the synthesis of a new series of dual hybrid
compounds consisting of the therapeutically used nonsteroidal-anti-inflammatory drugs …

Abstract Some novel 6, 8-diiodo-2-methyl-3-substituted-quinazolin-4 (3H)-ones bearing
sulfonamide derivatives (4–11) were synthesized in good yields and evaluated for their …

Among the class of nonsteroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors or
“coxibs” selectively inhibit the activity of the inducible isoform of cyclooxygenase. Moreover …

We have reported Riparin A as a promising antiparasitic molecule​​ against Leishmania
amazonensis promastigotes. This work evaluated the acute oral toxicity of Riparin A and its …

Pyrazoles, an important and well-known class of the azole family, have been found to show
a large number of applications in various fields, especially medicinal chemistry. Pyrazole …

Abstract Background/Aims: In this study we analyzed the mechanisms underlying celecoxib-
induced analgesia in a model of inflammatory pain in rats, using the intracerebroventricular …