More than half a century ago researchers thought that d-amino acids had a minor function
compared to l-enantiomers in biological processes. Many evidences have shown that d …

Since currently available antipsychotic medications predominantly treat hallucinations,
delusions, disorganized thoughts and behavior, and related agitation/aggression, attention …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

NMDA receptors (NMDARs) play an important role in neural plasticity including long-term
potentiation and long-term depression, which are likely to explain their importance for …

Severe psychiatric disorders such as schizophrenia are related to cognitive and negative
symptoms, which often are resistant to current treatment approaches. The glutamatergic …

D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of
many preclinical studies to ascertain the nature of its metabolism, its regional and cellular …

Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …

d-amino acids have been detected in a variety of peptides synthesized by animal cells.
These include opiate and antimicrobial peptides from amphibian skin, neuropeptides from …

Glutamatergic transmission in schizophrenia: from basic rese... : Current Opinion in Psychiatry
Glutamatergic transmission in schizophrenia: from basic research to clinical practice : Current …

Introduction: Abnormalities in glutamatergic neurotransmission mediated by N-methyl-d-
aspartate (NMDA) are implicated in the pathophysiology of schizophrenia, although the …