Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100
years of investigation, the etiology remains elusive and therapy ineffective. Despite current …

Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs)
mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) …

Despite the indispensable role that astrocytes play in the neurovascular unit, few studies
have investigated the functional impact of astrocyte signaling in cognitive decline and …

Converging lines of evidence associate gluco-regulatory abnormalities and peroxisome-
proliferator-activated receptor (PPAR) gamma function with increased risk for Alzheimer's …

Abstract Calcineurin (CaN), a Ca2+/calmodulin-activated serine/threonine phosphatase,
acts as a Ca2+-sensitive switch regulating cellular functions through protein …

Regulator of calcineurin 1 (RCAN1/MCIP1/DSCR1) regulates the calmodulin-dependent
phosphatase calcineurin. Because it is located on human chromosome 21, RCAN1 has …

Alzheimer's disease (AD) can be considered as a disease of memory in its initial clinical
stages. Amyloid-β (Aβ) peptide accumulation is central to the disease initiation leading later …

Synaptic dysfunction due to the disrupting binding of amyloid beta (Aβ) and tau oligomers is
one of the earliest impairments in Alzheimer's Disease (AD), driving initial cognitive deficits …

Background Amyloid β (Aβ) peptide is hypothesized to stimulate microglia to acquire their
characteristic proinflammatory phenotype in Alzheimer's disease (AD) brains. The specific …

Deterioration of the cortical cholinergic system is a leading neurochemical feature of
Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7 …