Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years

PL Collins, JA Melero - Virus research, 2011 - Elsevier
Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone
worldwide early in life and is a leading cause of severe lower respiratory tract disease in the …

Vaccines: the fourth century

SA Plotkin - Clinical and Vaccine Immunology, 2009 - Am Soc Microbiol
Vaccine development, which began with Edward Jenner's observations in the late 18th
century, has entered its 4th century. From its beginnings, with the use of whole organisms …

Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters

A Roberts, L Vogel, J Guarner, N Hayes… - Journal of …, 2005 - Am Soc Microbiol
Small animal models are needed in order to evaluate the efficacy of candidate vaccines and
antivirals directed against the severe acute respiratory syndrome coronavirus (SARS CoV) …

Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity

UJ Buchholz, A Bukreyev, L Yang… - Proceedings of the …, 2004 - National Acad Sciences
We investigated the contributions of the structural proteins of severe acute respiratory
syndrome (SARS) coronavirus (CoV) to protective immunity by expressing them individually …

Nipah virus: vaccination and passive protection studies in a hamster model

V Guillaume, H Contamin, P Loth… - Journal of …, 2004 - Am Soc Microbiol
Nipah virus, a member of the paramyxovirus family, was first isolated and identified in 1999
when the virus crossed the species barrier from fruit bats to pigs and then infected humans …

Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and …

Y Becker - Virus genes, 2006 - Springer
Infection of infants in their first year of life, children and elderly people with the respiratory
syncytial virus (RSV) endangers the life of the patient. An attempt to develop a formalin …

Live-attenuated respiratory syncytial virus vaccines

RA Karron, UJ Buchholz, PL Collins - Challenges and opportunities for …, 2013 - Springer
Live-attenuated respiratory syncytial virus (RSV) vaccines offer several advantages for
immunization of infants and young children:(1) they do not cause vaccine-associated …

Understanding the mechanisms of viral induced asthma: new therapeutic directions

NG Hansbro, JC Horvat, PA Wark… - Pharmacology & …, 2008 - Elsevier
Asthma is a common and debilitating disease that has substantially increased in prevalence
in Western Societies in the last 2 decades. Respiratory tract infections by respiratory …

Progress in the development of human parainfluenza virus vaccines

AC Schmidt, A Schaap-Nutt, EJ Bartlett… - Expert review of …, 2011 - Taylor & Francis
In children under 5 years of age, human parainfluenza viruses (HPIVs) as a group are the
second most common etiology of acute respiratory illness leading to hospitalization …

Recombinant Newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates

A Bukreyev, Z Huang, L Yang, S Elankumaran… - Journal of …, 2005 - Am Soc Microbiol
Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective
antigens of heterologous viruses can induce an effective immunity against the heterologous …