Baicalin mediated regulation of key signaling pathways in cancer

S Singh, A Meena, S Luqman - Pharmacological research, 2021 - Elsevier
Baicalin has been widely investigated against different types of malignancies both at the
cellular and molecular levels over the past few years. Due to its remarkable anti-proliferative …

Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells

H Taymaz-Nikerel, ME Karabekmez, S Eraslan… - Scientific reports, 2018 - nature.com
Doxorubicin is one of the most effective chemotherapy drugs used against solid tumors in
the treatment of several cancer types. Two different mechanisms,(i) intercalation of …

[HTML][HTML] Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

J Paluncic, Z Kovacevic, PJ Jansson… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

R Jain, MA Hussein, S Pierce, C Martens… - Pharmacological …, 2022 - Elsevier
Licorice (Glycyrrhiza glabra) is a well-known natural herb used to treat different ailments
since ancient times. Glycyrrhizin (GL), which is the primary triterpenoid compound of licorice …

Curcumin: modulator of key molecular signaling pathways in hormone-independent breast cancer

R Farghadani, R Naidu - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer remains the most commonly diagnosed cancer and the
leading cause of cancer death among females worldwide. It is a highly heterogeneous …

Unraveling the wide spectrum of melanoma biomarkers

A Revythis, S Shah, M Kutka, M Moschetta, MA Ozturk… - Diagnostics, 2021 - mdpi.com
The use of biomarkers in medicine has become essential in clinical practice in order to help
with diagnosis, prognostication and prediction of treatment response. Since Alexander …

The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer

A Arif, AA Alameri, UB Tariq, SA Ansari, HI Sakr… - International …, 2023 - Elsevier
Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

Therapeutic strategies involving survivin inhibition in cancer

D Martínez‐García, N Manero‐Rupérez… - Medicinal Research …, 2019 - Wiley Online Library
Survivin is a small protein that belongs to the inhibitor of apoptosis protein family. It is
abundantly expressed in tumors compared with adult differentiated tissues, being …

Investigation of antigen-specific T-cell receptor clusters in human cancers

H Zhang, L Liu, J Zhang, J Chen, J Ye, S Shukla… - Clinical Cancer …, 2020 - AACR
Purpose: Cancer antigen–specific T cells are key components in antitumor immune
response, yet their identification in the tumor microenvironment remains challenging, as …

A recent update on small‐molecule kinase inhibitors for targeted cancer therapy and their therapeutic insights from mass spectrometry‐based proteomic analysis

PY Lee, Y Yeoh, TY Low - The FEBS Journal, 2023 - Wiley Online Library
Kinases are key regulatory signalling proteins governing numerous essential biological
processes and cellular functions. Dysregulation of many protein kinases is associated with …