Context-specific signaling is a prevalent theme in cancer biology wherein individual
molecules and pathways can have multiple or even opposite effects depending on the tumor …

Extramedullary multiple myeloma (EMM) is an aggressive form of multiple myeloma (MM).
This study represents the most comprehensive next-generation sequencing analysis of EMM …

Abstract Background Circular RNAs (circRNAs) are a new class of noncoding RNAs that
have gained increased attention in human tumor research. However, the identification and …

Pleurocidin-family cationic antimicrobial peptide NRC-03 exhibits potent and selective
cytotoxicity towards cancer cells. However, the anticancer effect of NRC-03 in oral …

Evodiamine is a major alkaloid component found in the fruit of Evodia rutaecarpa. It shows
the anti-proliferative potential against a wide range of cancers by suppressing cell growth …

Osteosarcoma is a highly aggressive malignant tumor that is common in the pediatric
population and has a high rate of disability and mortality. Recent studies have suggested …

Many intracellular proteins are reversibly modified by O-linked GlcNAc (O-GlcNAc), a post-
translational modification that dynamically regulates fundamental cellular processes in …

Background Pathway enrichment analysis (PEA) is a common method for exploring
functions of hundreds of genes and identifying disease-risk pathways. Moreover, different …

Soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and
anti-proliferative effects have been studied in different cancer cells. However, the …

Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in
receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant …