Robustness is the quality of any relational object (biological or otherwise) to maintain its
components, its structure, and its function despite both external changes and endogenous …

Bacteria regulate gene expression to adapt to changing environments through
transcriptional regulatory networks (TRNs). Although extensively studied, no TRN is fully …

Gram-positive bacteria have developed elaborate mechanisms to control ammonium
assimilation, at the levels of both transcription and enzyme activity. In this review, the …

The genus Corynebacterium belongs to the taxonomic class Actinobacteria representing the
high G+ C branch of gram-positive bacteria. Among the most prominent members of this …

Specificity in protein–DNA recognition arises from the synergy of several factors that stem
from the structural and chemical signatures encoded within the targeted DNA molecule …

To understand non-trivial biological functions, it is crucial to develop minimal synthetic
models that capture their basic features. Here, we demonstrate a sequence-independent …

Efficient production of biochemicals using engineered microbes as whole-cell biocatalysts
requires robust cell viability. Robust viability leads to high productivity and improved …

The general central dogma frames the emergent properties of life, which make biology both
necessary and difficult to engineer. In a process engineering paradigm, each biological …

Wolbachia (Anaplasmataceae) is an endosymbiont of arthropods and nematodes that
resides within host cells and is well known for manipulating host biology to facilitate …

Metabolic engineering is a powerful tool to reprogramme cells to produce value-added
chemicals. Such engineering strategies require the fine-tuning of a cell's metabolism to …