[HTML][HTML] Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

Y Lu, FQ Bu, F Wang, L Liu, S Zhang, G Wang… - Translational …, 2023 - Springer
Physical exercise is of great significance for maintaining human health. Exercise can
provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently …

[HTML][HTML] Comprehensive approach to management of multiple sclerosis: addressing invisible symptoms—a narrative review

L Lakin, BE Davis, CC Binns, KM Currie… - Neurology and therapy, 2021 - Springer
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous
system, leading to neurodegeneration and manifesting as a variety of symptoms. These can …

Identifying the distinct cognitive phenotypes in multiple sclerosis

E De Meo, E Portaccio, A Giorgio, L Ruano… - JAMA …, 2021 - jamanetwork.com
Importance Cognitive impairment is a common and disabling feature of multiple sclerosis
(MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking …

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

[HTML][HTML] Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational Psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition

M Dubey, M Pascual-Garcia, K Helmes, DD Wever… - Elife, 2022 - elifesciences.org
Abstract Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically
involved in producing rapid network oscillations and cortical microcircuit computations, but …

Blood levels of brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS): A systematic review and meta-analysis

N Karimi, H Ashourizadeh, BA Pasha… - Multiple Sclerosis and …, 2022 - Elsevier
Background Multiple sclerosis is an autoimmune demyelinating disease marked by the
involvement of multiple pathophysiological pathways, including BDNF. BDNF (brain-derived …

Cerebrospinal fluid biomarkers and cognitive functions at multiple sclerosis diagnosis

E Virgilio, D Vecchio, I Crespi, C Puricelli, P Barbero… - Journal of …, 2022 - Springer
Cognitive impairment (CI) is a frequent and disabling symptom in Multiple Sclerosis (MS).
Axonal damage may contribute to CI development from early stages. Nevertheless, no …

[HTML][HTML] Task-and resting-state fMRI studies in multiple sclerosis: from regions to systems and time-varying analysis. Current status and future perspective

MA Rocca, MM Schoonheim, P Valsasina… - Neuroimage: Clinical, 2022 - Elsevier
Multiple sclerosis (MS) is a neurological disorder affecting the central nervous system and
features extensive functional brain changes that are poorly understood but relate strongly to …

[HTML][HTML] Cognitive impairment in multiple sclerosis: an update on assessment and management

E Portaccio, MP Amato - NeuroSci, 2022 - mdpi.com
Cognitive impairment (CI) is a core feature of multiple sclerosis (MS) and affects up to 65%
of patients in every phase of the disease, having a deep impact on all aspects of patients' …