During decades, the research field of cancer metabolism was based on the Warburg effect,
described almost one century ago. Lately, the key role of mitochondria in cancer …

Contrary to Warburg's original thesis, accelerated aerobic glycolysis is not a primary,
permanent and universal consequence of dysfunctional or impaired mitochondria …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Cell cycle progression and division is regulated by checkpoint controls and sequential
activation of cyclin-dependent kinases (CDKs). Understanding of how these events occur in …

Cancer is the second most important cause of death and new therapy modalities continue to
be developed and evolved. Cancer cells' metabolism is far different from the normal, healthy …

The tumour microenvironment is of critical importance in cancer development and
progression and includes the surrounding stromal and immune cells, extracellular matrix …

Purpose: Inhibition of monocarboxylate transporter (MCT) 1–mediated lactate transport may
have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose …

Metabolic reprogramming is one of the hallmarks of tumors. Alterations of cellular
metabolism not only contribute to tumor development, but also mediate the resistance of …

Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer death, has a
5-year survival rate of approximately 7–9%. The ineffectiveness of anti-PDAC therapies is …