Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …
airways has shown inefficient eradication of the infecting bacteria, as well as previously …
How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions Between Pseudomonas aeruginosa and Staphylococcus aureus
L Camus, P Briaud, F Vandenesch… - Frontiers in …, 2021 - frontiersin.org
Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …
Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa
is often accompanied by a reduction in bacterial growth rate. This reduction has been …
is often accompanied by a reduction in bacterial growth rate. This reduction has been …
From genotype to phenotype: adaptations of Pseudomonas aeruginosa to the cystic fibrosis environment
L Camus, F Vandenesch, K Moreau - Microbial genomics, 2021 - microbiologyresearch.org
Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …
Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa
A Simonis, C Kreer, A Albus, K Rox, B Yuan… - Cell, 2023 - cell.com
Drug-resistant Pseudomonas aeruginosa (PA) poses an emerging threat to human health
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …
Spectres of clock evolution: past, present, and yet to come
ML Jabbur, CH Johnson - Frontiers in Physiology, 2022 - frontiersin.org
Circadian clocks are phylogenetically widespread biological oscillators that allow organisms
to entrain to environmental cycles and use their steady-state phase relationship to anticipate …
to entrain to environmental cycles and use their steady-state phase relationship to anticipate …
Adapting to the Airways: Metabolic Requirements of Pseudomonas aeruginosa during the Infection of Cystic Fibrosis Patients
Pseudomonas aeruginosa is one of the major causes of morbidity and mortality of cystic
fibrosis patients. During the infection, the bacteria colonize the nutritional rich lung mucus …
fibrosis patients. During the infection, the bacteria colonize the nutritional rich lung mucus …
Polyclonality, Shared Strains, and Convergent Evolution in Chronic Cystic Fibrosis Staphylococcus aureus Airway Infection
Rationale: Staphylococcus aureus is the most common respiratory pathogen isolated from
patients with cystic fibrosis (CF) in the United States. Although modes of acquisition and …
patients with cystic fibrosis (CF) in the United States. Although modes of acquisition and …
Ceftolozane-tazobactam against Pseudomonas aeruginosa cystic fibrosis clinical isolates in the hollow-fiber infection model: challenges imposed by hypermutability …
Pseudomonas aeruginosa remains a challenge in chronic respiratory infections in cystic
fibrosis (CF). Ceftolozane-tazobactam has not yet been evaluated against multidrug …
fibrosis (CF). Ceftolozane-tazobactam has not yet been evaluated against multidrug …
Common adaptive strategies underlie within-host evolution of bacterial pathogens
YE Gatt, H Margalit - Molecular biology and evolution, 2021 - academic.oup.com
Within-host adaptation is a hallmark of chronic bacterial infections, involving substantial
genomic changes. Recent large-scale genomic data from prolonged infections allow the …
genomic changes. Recent large-scale genomic data from prolonged infections allow the …