An increasing amount of evidence suggests that bidirectional communication between the
gut microbiome and the central nervous system (CNS), which is also known as the …

Glioma is the most common primary malignant brain tumor in adults. It accounts for about
75% of such tumors and occurs more commonly in men. The incidence rate has been …

Most gastrointestinal diseases and disorders (GIDD) are associated with depression,
anxiety, and cognitive dysfunction. This suggests that shared features of GIDD, particularly …

Background and aims Inflammatory bowel disease (IBD), mainly categorized into Crohn's
disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that …

Background Crohn's disease (CD) is characterized by repetitive phases of remission and
exacerbation, the quality of life of patients with CD is strongly influenced by disease activity …

Abdominal pain in Crohn's disease (CD) has been known to be associated with changes in
the central nervous system. The periaqueductal gray (PAG) plays a well-established role in …

A growing body of evidence from neuroimaging studies suggests that inflammatory bowel
disease (IBD) is associated with functional and structural alterations in the central nervous …

Abstract Introduction Evidence suggests that Crohn's disease (CD) pathophysiology goes
beyond the gastrointestinal tract and is also strongly associated with the brain. In particular …

Alterations in grey matter volume (GMV) and cortical thickness (CT) in Crohn's disease (CD)
patients has been previously documented. However, the findings are inconsistent, and not a …

Pain is comprised of both sensory and affective components. The anterior cingulate cortex
(ACC) is a key brain region involved in the emotional processing of pain. Specifically …