Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

Myelin membranes are dominated by lipids while the complexity of their protein composition
has long been considered to be low. However, numerous additional myelin proteins have …

Since their original discovery, type I interferons (IFN-Is) have been closely associated with
antiviral immune responses. However, their biological functions go far beyond this role, with …

Introduction: Leukodystrophies constitute heterogenous group of rare heritable disorders
primarily affecting the white matter of central nervous system. These conditions are often …

Heritable neurological disorders provide insights into disease mechanisms that permit
development of novel therapeutic approaches including antisense oligonucleotides, RNA …

Metachromatic leukodystrophy (MLD) is an autosomal recessively inherited metabolic
disease characterized by deficient activity of the lysosomal enzyme arylsulfatase A. Its …

Objective In metachromatic leukodystrophy, a lysosomal storage disorder due to decreased
arylsulfatase A activity, hematopoietic stem cell transplantation may stop brain …

Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM)
changes on brain MRI, which often trigger biochemical and genetic confirmation of the …

Genetic leukoencephalopathies (gLEs) are a highly heterogeneous group of rare genetic
disorders. The spectrum of gLEs varies among patients of different ages. Distinct from the …