Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor …

Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

Animal cell shape is largely determined by the cortex, a thin actin network underlying the
plasma membrane in which myosin-driven stresses generate contractile tension. Tension …

Cell fate transitions are frequently accompanied by changes in cell shape and mechanics.
However, how cellular mechanics affects the instructive signaling pathways controlling cell …

When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

Mammalian embryos initiate morphogenesis with compaction, which is essential for
specifying the first lineages of the blastocyst. The 8-cell-stage mouse embryo compacts by …

The plasma membrane separates the interior of cells from the outside environment. The
membrane tension, defined as the force per unit length acting on a cross-section of …