Bradykinin (BK) metabolism and its receptors play a central role in drug-induced
angioedema (AE) without urticaria through increased vascular permeability. Many …

Background Hereditary angioedema is a rare genetic disease that leads to severe and
unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy based on …

Serine proteases are members of a large family of hydrolytic enzymes in which a particular
serine residue in the active site performs an essential role as a nucleophile, which is …

Background Hereditary angioedema is a rare and potentially life-threatening genetic
disease that is associated with kallikrein–kinin system dysregulation. Garadacimab …

Background Hereditary angioedema is characterized by recurrent and unpredictable
swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein …

Background Guidelines recommend effective on-demand therapy for all individuals with
hereditary angioedema. We aimed to assess the novel oral plasma kallikrein inhibitor …

Chronic spontaneous urticaria (CSU) is primarily a T2-dominant disease with a complex
genetic background. Skin mast cell activation can be induced not only via the IgE-FcεRI axis …

Introduction Many patients with rare diseases experience a diagnostic delay. Although
several quantitative studies have been reported, few studies have used a qualitative …

Background Hereditary angioedema (HAE) is a rare genetic disease with significant
morbidity and mortality for which early diagnosis and effective therapy are critical. Many Asia …

Abstract Background The Angioedema Control Test (AECT) is a patient‐reported outcome
measure developed and validated for the assessment of disease control in patients with …