Dysfunctional states of unconventional T-cell subsets in cancer
EN Katsnelson, A Spengler, J Domenico… - Journal of Leukocyte …, 2024 - academic.oup.com
Unconventional T cells represent a promising therapeutic agent to overcome the current
limitations of immunotherapies due to their universal T-cell receptors, ability to respond …
limitations of immunotherapies due to their universal T-cell receptors, ability to respond …
Tumor microenvironment of Burkitt lymphoma: different immune signatures with different clinical behavior.
MC Siciliano, G Bertolazzi, G Morello… - Blood …, 2024 - ashpublications.org
Burkitt lymphoma (BL) is characterized by tumor microenvironment (TME) in which
macrophages represent the main component, determining a distinct histological appearance …
macrophages represent the main component, determining a distinct histological appearance …
Integrated analysis of single-cell and bulk RNA sequencing data reveals a myeloid cell-related regulon predicting neoadjuvant immunotherapy response across …
H Liu, X Sima, B Xiao, H Gulizeba, S Zhao… - Journal of Translational …, 2024 - Springer
Background Immunotherapy has brought about a paradigm shift in the treatment of cancer.
However, the majority of patients exhibit resistance or become refractory to immunotherapy …
However, the majority of patients exhibit resistance or become refractory to immunotherapy …
Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency
G Wang, X Feng, J Ding - Structure, 2023 - cell.com
Summary Interferon regulatory factor 4 (IRF4) is a transcription factor that regulates the
development and function of immune cells. Recently, a new multimorphic mutation T95R …
development and function of immune cells. Recently, a new multimorphic mutation T95R …
Unveiling IRF4-steered regulation of context-dependent effector programs in Th17 and Treg cells
The transcription factor interferon regulatory factor 4 (IRF4) is crucial for the differentiation
and fate determination of pro-inflammatory T helper (Th) 17 and the functionally opposing …
and fate determination of pro-inflammatory T helper (Th) 17 and the functionally opposing …