Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
Nuclear compartmentalization as a mechanism of quantitative control of gene expression
Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
[HTML][HTML] Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
S Ambadipudi, J Biernat, D Riedel… - Nature …, 2017 - nature.com
The protein Tau aggregates into tangles in the brain of patients with Alzheimer's disease. In
solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules …
solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules …
Nuclear speckles: molecular organization, biological function and role in disease
L Galganski, MO Urbanek… - Nucleic acids …, 2017 - academic.oup.com
The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
Mechanisms and regulation of alternative pre-mRNA splicing
Y Lee, DC Rio - Annual review of biochemistry, 2015 - annualreviews.org
Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …
regulation of gene expression, providing significant expansion of the functional proteome of …
A day in the life of the spliceosome
One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
Coupling mRNA processing with transcription in time and space
DL Bentley - Nature Reviews Genetics, 2014 - nature.com
Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
Complexity of the alternative splicing landscape in plants
Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …
organisms to increase their coding potential and regulate gene expression through multiple …
RNA granules: functional compartments or incidental condensates?
RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
[HTML][HTML] CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
M Krajewska, R Dries, AV Grassetti, S Dust… - Nature …, 2019 - nature.com
Abstract Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by
phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects …
phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects …