A systematic review of implications, mechanisms, and stability of in vivo emergent resistance to colistin and tigecycline in Acinetobacter baumannii

S Karakonstantis - Journal of Chemotherapy, 2020 - Taylor & Francis
The potential of A. baumannii for acquired resistance to last resort antibiotics (colistin and
tigecycline) during treatment has important clinical implications, especially when dealing …

Chlorpromazine and amitriptyline are substrates and inhibitors of the AcrB multidrug efflux pump

EM Grimsey, C Fais, RL Marshall, V Ricci, ML Ciusa… - MBio, 2020 - Am Soc Microbiol
Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …

Methods and Challenges of Using the Greater Wax Moth (Galleria mellonella) as a Model Organism in Antimicrobial Compound Discovery

A Andrea, KA Krogfelt, H Jenssen - Microorganisms, 2019 - mdpi.com
Among non-mammalian infection model organisms, the larvae of the greater wax moth
Galleria mellonella have seen increasing popularity in recent years. Unlike other …

Prevalence of RND efflux pump regulator variants associated with tigecycline resistance in carbapenem-resistant Acinetobacter baumannii from a worldwide survey

K Lucaßen, C Müller, J Wille… - Journal of …, 2021 - academic.oup.com
Objectives To determine the most common tigecycline resistance mechanisms in
carbapenem-resistant Acinetobacter baumannii isolates obtained during the global …

Genomic and phenotypic evolution of tigecycline-resistant Acinetobacter baumannii in critically ill patients

J Zhang, J Xie, H Li, Z Wang, Y Yin, S Wang… - Microbiology …, 2022 - Am Soc Microbiol
Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A.
baumannii presently exhibits increasing antibiotic resistance, which poses great challenges …

Impact of target site mutations and plasmid associated resistance genes acquisition on resistance of Acinetobacter baumannii to fluoroquinolones

MA Mohammed, MTA Salim, BE Anwer… - Scientific Reports, 2021 - nature.com
Among bacterial species implicated in hospital-acquired infections are the emerging Pan-
Drug Resistant (PDR) and Extensively Drug-Resistant (XDR) Acinetobacter (A.) baumannii …

[HTML][HTML] The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible …

Q Xu, X Hua, J He, D Zhang, Q Chen, L Zhang… - International Journal of …, 2020 - Elsevier
Objective Acinetobacter baumannii has emerged as a problematic hospital pathogen and
tigecycline is among the few remaining antibiotics retaining activity against multidrug …

Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones

MA Mohammed, MT Ahmed, BE Anwer… - PloS one, 2020 - journals.plos.org
Nosocomial infections caused by extensively drug-resistant (XDR) or Pan-Drug resistant
(PDR) Acinetobacter (A.) baumannii have recently increased dramatically creating a medical …

Diversity of regulatory systems and their contribution to colistin and tigecycline resistance in Acinetobacter baumannii

S Gerson - 2021 - bonndoc.ulb.uni-bonn.de
Acinetobacter baumannii is a nosocomial pathogen which causes a wide range of serious
infections in critically ill patients in the intensive care unit. Besides its high desiccation …

Acinetobacter baumannii and Its Relationship to Carbapenem Resistance: A Meta-Analysis

DL Neres Rodrigues, FM Rodrigues da Costa… - 2022 - ri.conicet.gov.ar
Infections by antibiotic-resistant bacteria are a significant and complex global health issue.
In this context, Acinetobacter baumannii is particularly important because of its ability to …