Ankylosing spondylitis: an autoimmune or autoinflammatory disease?
Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
[HTML][HTML] Crosstalk between ER stress, autophagy and inflammation
S Chipurupalli, U Samavedam, N Robinson - Frontiers in Medicine, 2021 - frontiersin.org
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
[HTML][HTML] Cancer therapy by silver nanoparticles: fiction or reality?
As an emerging new class, metal nanoparticles and especially silver nanoparticles hold
great potential in the field of cancer biology. Due to cancer-specific targeting, the …
great potential in the field of cancer biology. Due to cancer-specific targeting, the …
ER stress: Autophagy induction, inhibition and selection
HO Rashid, RK Yadav, HR Kim, HJ Chae - Autophagy, 2015 - Taylor & Francis
An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
The interplay between exosomes and autophagy–partners in crime
The eukaryotic endomembrane system is a complex series of interconnected membranous
organelles that play important roles in responding to stress and maintaining cell …
organelles that play important roles in responding to stress and maintaining cell …
[HTML][HTML] Endoplasmic reticulum stress, unfolded protein response, and cancer cell fate
M Corazzari, M Gagliardi, GM Fimia… - Frontiers in oncology, 2017 - frontiersin.org
Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed
“ER stress” determining the activation of a finely regulated program defined as unfolded …
“ER stress” determining the activation of a finely regulated program defined as unfolded …
Impact of context-dependent autophagy states on tumor progression
M Assi, AC Kimmelman - Nature cancer, 2023 - nature.com
Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
[HTML][HTML] Immunogenic cell death and immunotherapy of multiple myeloma
Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a
wide variety of human tumors. For many years, apoptosis has been considered a non …
wide variety of human tumors. For many years, apoptosis has been considered a non …
Anticancer mechanisms of cannabinoids
In addition to the well-known palliative effects of cannabinoids on some cancer-associated
symptoms, a large body of evidence shows that these molecules can decrease tumour …
symptoms, a large body of evidence shows that these molecules can decrease tumour …
Towards the use of cannabinoids as antitumour agents
Various reports have shown that cannabinoids (the active components of marijuana and
their derivatives) can reduce tumour growth and progression in animal models of cancer, in …
their derivatives) can reduce tumour growth and progression in animal models of cancer, in …