In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main
cause of death. Treatment of lung disease to reduce the impact of infection, inflammation …

Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism
and is considered one of the most significant pathogens that produce chronic colonization …

Background Chronic infection and concomitant airway inflammation is the leading cause of
morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in …

Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated
with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P …

While complex intra-and interspecies microbial community dynamics are apparent during
chronic infections and likely alter patient health outcomes, our understanding of these …

Background Forced expiratory volume in 1 s (FEV 1) is an established marker of cystic
fibrosis (CF) disease progression that is used to capture clinical course and evaluate …

Cystic fibrosis is characterised by chronic polymicrobial infection and inflammation in the
airways of patients. Antibiotic treatment regimens, targeting recognised pathogens, have …

175 years have elapsed since John Hutchinson introduced the world to his version of an
apparatus that had been in development for nearly two centuries, the spirometer. Though he …

Background To better understand the relative effects of infection with nontuberculous
mycobacteria and Gram negative bacteria on lung function decline in cystic fibrosis, we …

A systematic review was performed (i) to describe the reported overall rate of progression of
CF lung disease quantified as FEV 1% predicted decline with age,(ii) to summarise …